Search results for "genetics [Transcriptome]"
showing 10 items of 3033 documents
Analysis and comparison of autologous platelet-rich plasma preparation systems used in the treatment of enthesopathies: A preliminary study
2021
Background Autologous platelet-rich plasma (PRP) injection is an alternative but widely accepted method for the treatment of degenerative changes in tendon attachments known as enthesopathies. The PRP is considered a safe source for high concentrations of the growth factors involved in the healing process. Despite initial promising outcomes, many recent studies report conflicting results for this treatment. This may be due to differences in the concentrations of platelets and growth factors in PRPs obtained using different methods. Objectives The aim of this study was to compare PRP preparation systems in terms of morphotic components and selected growth factors to find the most appropriate…
The mechanisms of thrombotic risk induced by hormone replacement therapy.
2001
Abstract Objective : To review the available information on the action of hormones on the mechanisms involved in thrombotic risk. Results and Conclusions : Thrombosis plays a crucial role in the genesis and progression of both coronary heart disease (CHD) and venous thromboembolic disease (VTED), the two main forms of cardiovascular disease. Two main determinants of the thromboembolic phenotype, hypercoagulable state and altered endothelium, accumulate much of the work performed on the influence of hormones on thrombosis. Information has accumulated mainly for oestrogens, but increasing evidences support a role for progestogens. The sensitivity of each of the three components of the hemosta…
Inhibition of inflammatory responses by epitaondiol and other marine natural products
1995
The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependen…
Shortstop Recruits EB1/APC1 and Promotes Microtubule Assembly at the Muscle-Tendon Junction
2003
Abstract Background: Shot (previously named Kakapo), is a Drosophila Plakin family member containing both Actin binding and microtubule binding domains. In Drosophila , it is required for a wide range of processes, including axon extension, dendrite formation, axonal terminal arborization at the neuromuscular junction, tendon cell development, and adhesion of wing epithelium. Results: To address how Shot exerts its activity at the molecular level, we investigated the molecular interactions of Shot with candidate proteins in mature larval tendon cells. We show that Shot colocalizes with EB1/APC1 and with a compact microtubule array extending between the muscle-tendon junction and the cuticle…
Bis(dimethylammonium) pentachloroantimonate(III), on the deformation of the octahedral coordination of Sb III
1998
The structure of the title compound, [NH2(CH3)2]2SbCl5, was determined at 295 and 85 K. It consists of polymeric (SbCl52−)n chains composed of deformed SbCl63− octahedra connected by corners and dimethylammonium cations. The temperature dependence of the Sb–Cl bond lengths is discussed. It is argued that the deformation of the octahedral coordination of the SbIII atom is caused by electrostatic interaction/hydrogen bonds.
Variable-temperature X-ray crystal structure determinations of {Fe[tren(6-Mepy)3]}(ClO4)2and {Zn[tren(6-Mepy)3]}(ClO4)2compounds: correlation of the …
2007
Variable-temperature X-ray crystal structure determinations (80–330 K) on compounds {Fe[tren(6-Mepy)3]}(ClO4)2(1-Fe) {tren(6-Mepy)3is tris[3-aza-4-(6-methyl-2-pyridyl)but-3-enyl]amine} and {Zn[tren(6-Mepy)3]}(ClO4)2(1-Zn) {tren(6-Mepy)3is tris[3-aza-4-(6-methyl-2-pyridyl)but-3-enyl]amine} were carried out together with a detailed analysis of the unit-cell volume and parameters in the spin transition region for (1-Fe). Both compounds crystallize in the monoclinic system and retained the space groupP21/cat all measured temperatures. The Fe and Zn atoms are surrounded by six N atoms belonging to imine groups and pyridine groups of the trifurcated ligand, adopting a pseudo-octahedral symmetry. …
The deformation tensor ∊ of the spin transition in the mixed crystal [Fe0.46Zn0.54(ptz)6](BF4)2
2004
The conversion of the spin state of complexes exhibiting thermal spin crossover from the1A1low-spin (LS) state to the5T2high-spin (HS) state is accompanied by a deformation of the lattice due to the larger bond lengths in the HS state as compared with the LS state. In a previous work [Kuszet al.(2000).J. Appl. Cryst.33, 201–205], it has been shown that the deformation of the lattice, corrected for its temperature dependence, can be described by an almost temperature-independent tensor ∊ multiplied by the fraction of molecules in the HS state, γHS. Here the dependence of ∊ in a mixed single crystal of [Fe0.46Zn0.54(ptz)6](BF4)2(ptz = propyltetrazole) with a transition temperature near 110 K …
Octahedral distortion caused by hydrogen bonding in tris(diethylammonium) hexachloridoantimonate(III).
2010
The factors influencing the distortion of inorganic anions in the structures of chloridoantimonates(III) with organic cations, in spite of numerous structural studies on those compounds, have not been clearly described and separated. The title compound, [(C(2)H(5))(2)NH(2)](3)[SbCl(6)], consisting of isolated distorted [SbCl(6)](3-) octahedra that have C(3) symmetry and [(C(2)H(5))(2)NH(2)](+) cations, unequivocally shows the role played by hydrogen bonding in the geometry variations of inorganic anions. The organic cations, which are linked to the inorganic substructure through N-H...Cl hydrogen bonds, are clearly responsible for the distortion of the octahedral coordination of Sb(III) in …
Quantitative Anatomical Studies
2015
This special issue of this journal highlights new developments mainly in the field of quantification of the data of anatomical studies. In this special issue, we reviewed and edited seventeen articles from broad ranges of anatomical studies. N. Utkualp and I. Ercan reviewed anthropometric measurement usage in medical sciences from Ancient Egyptian, Greek, and Roman civilizations to those from modern medicine. They also stressed contributions of the well-known scientists to recent diagnostic methods. S. Liao et al. studied the fundamental problem of automatically segmenting teeth in dental mesh models into individual tooth objects and they built a novel dental-targeted harmonic field, which …
Expectation of sensory stimulation modulates brain activation during visual motion stimulation.
2005
The differential effects of visual hemifield motion stimulation during fixation of a stationary target were compared under two conditions: fixation straight ahead without any further instructions and fixation straight ahead with attention shifted to the "dark hemifield." Data from nine right-handed volunteers revealed that striate and extrastriate right hemispheric visual areas exhibited larger activations during left hemifield motion stimulation when attention was shifted to the right dark hemifield. Montreal Neurological Institute (MNI) coordinates (26, -98, -4) of the additional clusters activated in the latter condition corresponded best to the kinetic occipital region, which is known t…